Running title: Orexin (Hypocretin) Receptor Agonists and Antagonists for Treatment of Sleep Disorders Orexin (Hypocretin) Receptor Agonists and Antagonists for Treatment of Sleep Disorders Rationale for Development and Current Status
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*KURAに登録されているコンテンツの利用については,著作権法に規定されている私的使用や引用などの範囲内で行ってください。 *著作権法に規定されている私的使用や引用などの範囲を超える利用を行う場合には,著作権者の許諾を得てください。ただし,著作権者 から著作権等管理事業者(学術著作権協会,日本著作出版権管理システムなど)に権利委託されているコンテンツの利用手続については ,各著作権等管理事業者に確認してください。 Title Orexin (Hypocretin) receptor agonists and antagonists for treatment of sleep disorders: Rationale for development and current status Author(s) Mieda, Michihiro; Sakurai, Takeshi Citation CNS Drugs, 27(2): 83-90 Issue Date 2013 Type Journal Article Text version author URL http://hdl.handle.net/2297/34649 Right
منابع مشابه
Hypocretin receptor antagonists for insomnia: rationale and clinical data
Loss of hypocretin neurons leads to sleep attacks and cataplexy in a rare sleep disorder known as narcolepsy. The hypocretin system stabilizes states of wakefulness and sleep through complex neural pathways. Insomnia, on the other hand, is a common sleep disorder characterized as difficulty initiating or maintaining sleep. Current treatment options for insomnia are limited to cognitive-behavior...
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The hypocretin (Hcrt), also known as orexin, peptides are essential for arousal stability. Here we discuss background information about the interaction of Hcrt with other neuromodulators, including norepinephrine and acetylcholine probed with optogenetics. We conclude that Hcrt neurons integrate metabolic, circadian and limbic inputs and convey this information to a network of neuromodulators, ...
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تاریخ انتشار 2017